Physicians reported “placenta on a chip” – BBC

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Researchers from the University of Pennsylvania have developed the first “placenta on a chip”, which fully simulates the transfer of nutrients through the placental barrier. Read more about the development can be found in Lab on a Chip journal, and briefly about her reports RNS.

The silicone-sized flash storage device comprises two layers of human cells. On both sides of layers arranged microchannels separated by a porous membrane. On one side are far trophoblast cells, and on the other – endothelial cells. Endothelial cells are cells that line blood vessels and trophoblast – outer cell layer mammalian blastocyst through which nutrients pass from the fetus to the maternal organism. Layers, according to scientists, and simulate the placental barrier.

«This barrier mediates all traffic between mother and fetus during pregnancy. Nutrients and foreign agents such as viruses, or transported across the barrier, or stop, “- the researchers note. In the new study, the authors studies have shown that the two layers of cells continue to grow and develop. “Placental cells change during pregnancy. Placental trophoblast cells actually merge with each other to form a tissue called syncytia. The barrier also becomes thinner in the course of pregnancy, and in our model, we can reproduce these changes “, – underline the researchers

The authors point out that the plan to use the device to study metabolic processes that accompany premature birth

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